Comet Assay

State-of-the-art comet images

The team recently published an important manuscript showing an interplay between the linker histone Hho1p and Arp4p (a constituent of three chromatin modifying complexes in yeast)

Int J Biochem Cell Biol. 2014 Dec 24;59C:182-192. doi: 10.1016/j.biocel.2014.12.006. [Epub ahead of print] The linker histone in Saccharomyces cerevisiae interacts with actin-related protein 4 and both regulate chromatin structure and cellular morphology.   Georgieva M1, Staneva D1, Uzunova K1, Efremov T1, Balashev K2, Harata M3, Miloshev G4. Author information Abstract Chromatin structure promotes important epigenetic mechanisms that regulate cellular fate by organizing, preserving and controlling the way by which the genetic information works. Our understanding of chromatin and its functions is sparse and not yet well defined. The uncertainty comes from the complexity of...