Български
| Professor in Molecular Biology | |||
| Interests: Genetics and Epigenetics | |||
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 E-mail: milenageorgy@gmail.com milenaki@chromatinepigenetics.com Tel: (+359) 2 979 36 97 |
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| Name | Milena Georgieva Vasileva |
| Citizenship | Bulgarian |
| Language proficiency | English – fluent Spanish – fluent Russian – good |
| Address | Institute of Molecular Biology "Acad. R. Tsanev" Bulgarian Academy of Sciences (BAS) Molecular Genetics Lab “Acad. G. Bonchev” str., bl. 21, lab 523 1113 Sofia, Bulgaria |
| Telephone | (+359) 2 979 36 97 |
| milenaki@chromatinepigenetics.com milenageorgy@gmail.com |
| 2023 - 2024 2016 – 2023 |
Professor at he Institute of Molecular Biology, BAS Associate professor at the Institute of Molecular Biology, BAS |
| 2010 – 2016 | Assistant professor the Institute of Molecular Biology, BAS, Sofia |
| 2009, July | PhD in Molecular Biology Thesis title: “Structural and functional significance of linker histone Hho1p for Saccharomyces cerevisiae chromatin” |
| 2004 – 2009 | PhD student - Institute of Molecular Biology “Acad. R. Tsanev”, BAS |
| 2001 – 2004 | Research assistant at the Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia |
| 2001, May | MSc in Pedagogy (teacher in Biology) |
| 1999 – 2001 | MSc. student in Biology Pedagogy |
| 2001, October | MSc. in Cellular and Developmental Biology |
| 1996 – 2001 | MSc student in Cellular and Developmental Biology, Faculty of Biology, Sofia University, Bulgaria Diploma thesis “Antitumor activities of isoquinoline alkaloids” |
| 1991 – 1996 | Secondary English Language School “Dr. P. Beron” Kyustendil, Bulgaria |
| 2010 – 2013 | Research Project at the Bulgarian Science Fund - A detailed study of the role of yeast linker histone Hho1p in the processes of chromatin remodeling Grant number: DMU 02/8, “Young Researchers Competition”, Section Biology |
| 2018 - 2021 | Research project at the Bulgarian Science Fund: "Investigation of the ecological pressure in the Bulgarian Black sea aquatory using the Black sea mussel Mytilus galloprovincialis Lam as a model through integrated microbiological, biochemical and molecular biology markers" |
| 2017 – 2020 | Research project at the Bulgarian Science Fund: "Chromatin structure and dynamics during the lifespan of living organisms – elucidating the most intricate mechanisms that govern cellular fate" |
| 2018 - 2020 | Research project at the Bulgarian Science Fund: "Natural Deep Eutectic Solvents (NADES)" |
| 2017 - 2020 | NATO SPS MYP Project G5266: "Field detector for genotoxicity by CBRN and explosive devices" |
2016 – 2019 | Research project at the Bulgarian Science Fund “Molecular mechanisms of immune tolerance - importance for endocrine function of regulatory T-cells.” |
| 2010 – 2014 | Research project at the Bulgarian Science Fund, Grant number DID 02/35. “Study on some molecular mechanisms by which fragile X mental retardation protein 1 in Drosophila melanogaster (dFMRP1) controls some aspects of neuronal development.” |
| 2011 – 2013 | Research project at the Bulgarian Science Fund, Grant number DDVU 02/61. “Enviromental pollution impact on the ionome of natural populations of dandelion for monitoring purposes”. |
| 2009 – 2011 | European Commission, European Social Fund, Human Resources Development “Young Scientists’ support for career development” Grant number: BG 051 PO 001-3.3.04/58. |
| 2005 – 2006 | Research project at the Bulgarian Science Fund – Optimization of a novel test for detection of DNA damaging agents in food; Grant number: MU - B-1512/05, “Young Scientists’ Call”, Section Biology |
| 2004 – 2006 | Research project at the Bulgarian Science Fund - Molecular markers in plant taxonomy – application of the RAPD method in the taxonomic study of Galanthus L. in Bulgaria; Grant number: MU - B -1407/04, Section Biology |
| 2004 – present | Assistant supervisor in practical exercises of BSc and MSc degree Molecular Biology students in the summer semester courses “Regulation of Gene Activity” and “Apoptosis” at the Faculty of Biology, Sofia University |
| 2008 – 2012 | An invited lecturer at the summer semester course “Regulation of Gene Activity”, Faculty of Biology, SU; Lectures’ titles: “Posttranslational modifications of histone proteins”, “Cross-talk of posttranslational histone modifications” and “Processes of chromatin remodeling” |
| 2007 – 2009 | Scientific advisor of an undergraduate student on his Master degree thesis preparation: “Epigenetic significance of histone H1 zero in the development of human gliomas” |
| 2004 – present | Union of Scientists in Bulgaria |
| 2003 – present | FEBS constituent society |
| 2017 – present | Society of Cancer Epigenetics |
| 2011 | Best Young Investigator in the field of Biomedicine - The Union of Bulgarian Scientists |
| 2010 – 2011 | National Scholarship Programme at the World Federation of Scientists |
| 2010 | Best Young Investigator - The Union of Bulgarian Scientists |
| 2007 | Best Young Investigator - The Union of Bulgarian Scientists; Stara Zagora, International Scientific Conference |
| 2006 | Best Young Investigator - The Union of Bulgarian Scientists |
| 2011 | CBM Summer School 2011 on the topics of Active and Healthy Aging - 11th - 13th July, 2011, Trieste, Italy |
| 2009 | CEEPUS international summer school: Bioanalysis, Blagoevgrad, Bulgaria, 6 – 12 Sept., 2009 |
| 2008 | FEBS advanced course: “Microspectroscopy: Monitoring molecular interactions in living cells”, Wageningen, the Netherlands, 21-27 September, 2008 |
| 2007 | ECDO training courses: Concepts and methods in programmed cell death, Portoroz, Slovenia, 26-27 October, 2007 |
| 2006 | Marie Curie advanced course: Third Course on Epigenetics, Paris, France, 17-25 Oct, 2006 |
| 2006 | EBSA course: – Sofia School of Protein Sciences, Sofia, Bulgaria, 20-28 Sept, 2006 |
| 2002 | FEBS course: Basic Methods in Yeast Genetics and Molecular Biology, Strasbourg, France, 7-20 July, 2002 |
2017 | 15th International Congress of Histochemistry and Cytochemistry “From Molecules to Diseases” - May 18 - 21, 2017, Antalya, Turkey
Invited talk: ▪ Epigenetic significance of higher-order chromatin organization in health and disease |
2017 | European Scientists’ Night – 30th Sept., 2017, Sofia, Bulgaria Invited talk: ▪ Molecular Biology – challenges and perspectives |
2017 | OSEM live – 8th October, 2017 Invited talk: ▪ Epigenetics |
2017 | Festival The Freedom to be – 21st, October, 2017, Sofia, Bulgaria Invited talk: ▪ Epigenetics - the magic to age healthily |
2017 | Orange career paths – 21st October, 2017, Sofia, Bulgaria Invited talk: ▪ Vocation SCIENTIST |
2017 | TEDxSofia – 3rd June, Sofia, Bulgaria Invited talk: ▪ The secrets hidden in the human genome |
2017 | Festival The Freedom to be – 8th April, 2017, Sofia, Bulgaria Invited talk: ▪ The Freedom to change your genome |
2016 | European Scientists’ Night – 30th Sept., 2016, Ruse, Bulgaria Invited talk: ▪ To prepare a GENEial recipe |
2016 | European Youth parliament - 23 - 24 Jan., 2016, Sofia Invited talk: ▪ Augmented human - optimizing the human |
| 2016 | Epiconcept - Epigenetics and Periconception environment COST Action FA1201 - "Cross species epigenetics, gametogenesis and embryogenesis" - 17 - 19 May, 2016, Velingrad, Bulgaria Invited talk: ▪ Impact of human sperm chromatin organization on sperm quality |
| 2016 | Advanced Research Workshop - NATO SPS - Benchmarking Telemedicine: Improving Health security on the Balkans - 15 - 17 Nov., 2016, Skopje, FYRM Invited talk: ▪ TeleGenetics - bringing Telemedicine closer to the new era of personalized medicine |
2016 | First Anti-ageing Symposium - 19 - 20 Nov., 2016, Sofia Invited talk: ▪ Epigenetic Antiageing perspectives |
| 2015 | XXVth International Scientific Conference dedicated to 50 Anniversary of the Union of Scientists in Stara Zagora – 4th – 5th June, Stara Zagora Talk: ▪ Saccharomyces cerevisiae chromatin mutants exhibit premature ageing phenotypes. Poster: ▪ Epigenetic significance of chromatin structure in cellular ageing |
| 2015 | 14th International Symposium on Immunology of Reproduction – 22nd – 24th May, 2015, Varna, Bulgaria Poster: ▪ Advantages of human sperm DNA damage detection by the method of Comet Assay . |
| 2015 | Sixth Workshop on Experimental Models and Methods in Biomedical Research – 12th – 14th May, 2015, Sofia, Bulgaria Invited talk: ▪ Saccharomyces cerevisiae – a brilliant model for studying ageing. Invited talk: ▪ Chromatin - the main player in the ageing process. |
| 2015 | Mini_symposium “Epigenetics and Chromatin structure” – 31st March, 2015, LIMES, under the initiative “Women in Science” Invited talk: ▪ Epigenetic Significance of higher-order chromatin structures for cellular stress resistance and longevity. |
| 2015 | 13th International Congress on Targeted Anticancer Therapies (TAT 2015) - Paris, France, 2-4 March 2015 Poster: ▪ INFLUENCE OF DEOXYCHOLIC ACID AND ITS METAL COMPLEXES ON VIABILITY AND PROLIFERATION OF HUMAN TUMOR CELL LINES L. Dyakova, T. Zhivkova, A. Abudalleh, D.-C. Culita, G. Marinescu, L. Patron, M. Georgieva, G. Miloshev, R. Kalfin, R. Alexandrova Poster: ▪ METAL COMPLEXES OF MELOXICAM AND ISOXICAM DECREASE VIABILITY AND PROLIFERATION OF VIRUS-TRANSFORMED CANCER CELLS T. Zhivkova, R. Alexandrova, L. Dyakova, M. Georgieva, G. Miloshev, D.-C. Culita, G. Marinescu, L. Patron, M. Alexandrov |
| 2014 | 2nd Academy on Reproductive Medicine – Vienna In Vitro Center, Tokuda hospital, Sofia, Bulgaria, 4th October, 2104 Invited talk: ▪ Epigenetics – This is Our future. |
| 2014 | X IMYA – Xth International Meeting on Yeast Apoptosis – 14 – 18th May, Gotebourg, Sweden. Invited talk: ▪ Chromatin remodeling as a modulator of ageing |
| 2013 | TEDxAUBG – Shake up your mind – 13th April, 2013, Blagoevgrad, Bulgaria Talk: ▪ Shaping our lives through genetics, epigenetics and the environment |
| 2013 | Experimental methods and models in biomedical research – 27 – 29th May, 2013, Sofia, Bulgaria. Talk: ▪ CHANGES IN CHROMATIN STRUCTURE REVEALED BY CHROMATIN COMET ASSAY (ChCA) IN THE FRAGILE X CHROMOSOME SYNDROME MODEL DROSOPHILA MELANOGASTER Talk: ▪ CHROMATIN COMET ASSAY – A POWERFFUL TOOL FOR MONITORING CHROMATIN ORGANIZATION DURING AGEING |
| 2012 | Experimental Models and Methods in Biomedical Research – 23rd -25th April 2012, Sofia, Bulgaria Talk: ▪ Does the budding yeast linker histone hho1p influence survival and morphology of chronologically aging cells? |
| 2012 | International Scientific Conference Stara Zagora, 7th – 8th June, 2012, Stara Zagora, Bulgaria Talk: ▪ The linker histone of Saccharomyces cerevisiae influences yeast chronological aging. |
| 2012 | EMBO Conference “Gene Transcription in Yeast - From Mechanisms to Gene Regulatory Networks” - 16 – 21 st June, 2012, Girona, Spain Poster: ▪ The interaction between S. cerevisiae linker histone Hho1p and Arp4p affects chromatin remodeling. Poster: ▪ The linker histone Hho1p is crucial for the proper organization of S. cerevisiae higher-order chromatin structure |
| 2011 | 2nd IMPPC Conference “Signaling to Chromatin”, Barcelona, Spain, 31st March - 1st April, 2011. Poster: ▪ Hho1p, the linker histone of Saccharomyces cerevisiae - can yeast cells manage without it? Poster: ▪ Yeast Kluyveromyces lactis - a model for studying human linker histone H1 zero. |
| 2011 | Experimental models and methods in Biomedicine, 16 - 18th May, 2011, Sofia, Bulgaria. Talk: ▪ Drosophila as an experimental model to study the fragile X chromosome syndrome. Talk: ▪ Studying aging of the genome in the model system Saccharomyces cerevisiae. |
| 2011 | 21st International Scientific Conference, Stara Zagora, Bulgaria, 2 - 3rd June, 2011. Talk: ▪ How important are the higher-order chromatin structures for the proper gene expression? Talk: ▪ Environmental pollution with heavy metals and its influence on the ionome of Taraxacum officinale. Poster: ▪ Is there a linker histone in the yeast Kluyveromyces lactis? |
| 2011 | 4th International Congress of Molecular Medicine - Istanbul, Turkey, 28th - 30th June, 2011. Talk: ▪ In vivo interactions of S. cerevisiae linker histone with chromatin remodeling complexes. Poster: ▪ Saccharomyces cerevisiae - a promising tool for studying human brain tumors. Poster: ▪ Study of the higher-order chromatin structure in fragile X mental retardation gene (FMR1) knock-out Drosophila mutants. |
| 2011 | 22nd American Peptide Symposium – Harbor Island, San Diego, USA, 25 – 30 June, 2011. Talk: In vitro assessment of the cytotoxic effects of novel RGD-Mimetics |
| 2011 | EMBO Conference Series “Nuclear Structure and Dynamics” - L’Isle Sur la Sorgue, France, 28 Sept. – 2 October, 2011. Poster: ▪ The linker histone of Saccharomyces cerevisiae, Hho1p, is a moderator of chromatin organization in vivo. Poster: ▪ In vivo interactions of Saccharomyces cerevisiae linker histone with chromatin remodeling complexes. |
| 2011 | Anniversary Molecular Biology Conference – 50 Years Institute of Molecular Biology, 6-7th October, 2011, Sofia, Bulgaria. Talk: ▪ The influence of the remodeling complex INO80 on the higher-order chromatin structures of yeast Saccharomyces cerevisiae. |
| 2011 | 7th Balkan Congress of Microbiology, 25-29th October, 2011, Belgrade, Serbia. Poster: ▪ Dessislava Staneva, E. Peycheva, M. Georgieva, B. Boteva and G. Miloshev. 2011. Sensitivity of the yeasts Kluyveromyces lactis and Saccharomyces cerevisiae to genotoxic agents studied by Comet Assay – a comparative study |
| 2011 | 6th Workshop on Biological activities of metals, synthetic compounds and natural products -Sofia, Bulgaria, 28 – 30 November, 2011 Talk: ▪ Our first steps in tissue engineering? |
| 2010 | International workshop on Experimental Models and Methods for Biomedical Research, Sofia, Bulgaria 17-17 March, 2010. Talk: ▪ Saccharomyces cerevisiae - model organism for study of human diseases |
| 2010 | 20 th Anniversary International Scientific Conference. Stara Zagora 3rd – 4th June, 2010. Talk: ▪ The yeast Saccharomyces cerevisiae and their potentials for studying of human gliomas. |
| 2010 | Yeast, an evergreen model, Sapienza Uni, Rome, 22 – 25th Sept. 2010 Poster: ▪ Deletion of the linker histone Hho1p suppresses arp4 mutant phenotype in Saccharomyces cerevisiae. Talk: ▪ Saccharomyces cerevisiae, a model for linker histone and higher-order chromatin structure studies |
| 2010 | 3rd SFB TR5 Symposium on Chromatin – Assembly and Inheritance of Functional States, Munich, Germany, 6th – 8th October, 2010. Poster: ▪ Hho1p – the linker histone of Saccharomyces cerevisiae plays an important role in chromatin organization |
| 2009 | International Scientific Conference: Stara Zagora, Bulgaria, 4-5 June, 2009; Talk: ▪ Effect of the transcription factor Sub1 on S. cerevisiae chromatin organization. Talk: ▪ Hho1p and its role in the processes of chromatin remodeling |
| 2009 | Bulgarian–Japanese Symposium “Genomics and Proteomics in Personalized Medicine”, Sofia, Bulgaria 19-20 March, 2009. Poster: ▪ Development of a molecular marker for personalized diagnostics of human glioma tumors |
| 2009 | CEEPUS International Symposium and Summer School on Bioanalysis. Blagoevgrad, Bulgaria 6-12 September, 2009. Talk: ▪ The method of Comet Assay in Bioanalysis Poster: ▪ Genotoxic sensitivity of Kluyveromyces lactis assessed by Comet Assay |
| 2008 | MC-GARD Conference: Interplay among genetics, epigenetics and small RNAs, Madrid, Spain, 4-7th May, 2008; Poster: ▪ Epigenetic significance of Histone H10 in development of human gliomas |
| 2008 | EMBO Workshop: Gene transcription in yeast: Sant Feliu de Gauxols,(Costa Brava), Spain, 21-26 June, 2008; Poster : ▪ Act3p/Arp4 interacts with linker histone Hho1p in S. cerevisiae nuclei in vivo and thus both maintain higher-order chromatin structure in concert Poster: ▪ Chromatin loop organization in HMG1 KO mutant |
| 2007 | Scientific Conference for PhD students and young scientists:Plovdiv, Bulgaria, 24 March, 2007; Talk: ▪ Molecular and cell- biological methods for detection of the effects of Bulgarian propolis |
| 2007 | International Scientific Conference: Stara Zagora, Bulgaria, 7-8 June, 2007; Talk: Chromatin remodeling complexes and their roles in higher-ordered structuring of chromatin |
| 2007 | 15th Conference on Apoptosis: Portoroz, Slovenia, 26-31 October 2007; Poster: ▪ Cellular death in Glioblastoma multiforme |
| 2007 | 20th International meeting on “The Biology of Kluyveromyces lactis”, Orsay, France, 7-9 Sept., 2007; Poster: Single-Cell Gel Electrophoresis (SCGE) on Kluyveromyces lactis |
| 2017 | Georgieva, M., Staneva, D. and Miloshev, G. 2017 TeleGenetics – Bringing Telemedicine Closer to the New Era of Personalized Medicine In Benchmarking Telemedicine: Improving Health Security in the Balkans,IOS press, Editor Stone, C.S., pp: 42-48,DOI:10.3233/978-1-61499-812-9-42, ISBN print 978-1-61499-811-2; ISBN online 978-1-61499-812-9 |
| 2017 | Miloshev, G., Staneva, D. and Georgieva, M. 2017 Genetics and Epigenetics in Telemedicine In Benchmarking Telemedicine: Improving Health Security in the Balkans,IOS press, Editor Stone, C.S., pp: 37-41,DOI:10.3233/978-1-61499-812-9-37,ISBN print 978-1-61499-811-2; ISBN online 978-1-61499-812-9 |
| 2016 | Staneva, D., Georgieva, M. and Miloshev, G. 2016 Klyuveromices lactis harbours a functional linker histone encoding gene FEMS Yeast Res, Volume 16 (4), April 2016, Pages 182-192 |
| 2016 | Vasileva, B., Georgieva, M., Staneva, D., Zagorchev, P. and Miloshev, G. 2016 Chromatin modulates cellular response to UV light during the process of chronological ageing International Comptes Rendus de l'Academie Bulgare de Sciences , Volume 69 (12), Pages1592-1602 |
| 2016 | Georgieva, M., Staneva, D. and Miloshev, G. Epigenetic significance of chromatin during cellular ageing and organismal lifespan In D. Hollar and D. Vasudevan (Eds.) Epigenetics, the environment and children's health across lifespans, New York, Springer, pp 21-66, ISBN: 978-3-319- 25323-7. |
| 2015 | Georgieva, M., Staneva, D., Uzunova, K., Еfremоv, T., Balashev, K., Harata, M. 2015 Miloshev, G. The linker histone in Saccharomyces cerevisiae interacts with actin-related protein 4 and both regulate chromatin structure and cellular morphology International Journal of Biochemistry and Cell Biology, Volume 59, February 2015, Pages 182-192 |
| 2013 | Staneva, D., Peycheva, E., Georgieva, M., Еfremоv, T. and Miloshev, G. 2012. Application of comet assay for the assessment of DNA damage caused by chemical genotoxins in the dairy yeast Kluyveromyces lactis. Antonie van Leeuwenhoek 103: 143 – 152 |
| 2012 | Miloshev G. and Georgieva M., 2012. The linker histone and chromatin of yeast Saccharomyces cerevisiae. In: Histones: Class, Structure and Function (Chang-Hui Shen, ed.), Nova Science Publishers, NY, USA (2012) pp. 59 - 75, ISBN: 978-1-62100-274-1 |
| 2012 | Alexandrova, R.I., Zhivkova, T., Alexandrov, M., Miloshev, G., Georgieva, M., Pantcheva I., Mitewa, M. 2012. Cytostatic and cytotoxic properties of Monensic acid and its biometal(II) complexes against human tumor / non-tumor cell lines. Central European Journal of Chemistry (in press) ISSN: 1895-1066 |
| 2012 | Peycheva, E., Tashev, A., Vasileva, Y., Staneva, D., Georgieva, M., Miloshev, G. 2012. Genome rearrangements in the common dandelion Taraxacum officinale web. Collected from sites polluted with heavy metals. Comptes Rendus de l’Academie Bulgare, des Sciences, 65 (6): 807 – 814, ISSN: 1310-1331 |
| 2012 | Georgieva M., Staneva D., Uzunova K. and Miloshev G. 2012. The deletion of the gene for the linker histone in arp 4 mutant yeast cells is not deleterious. Biotechnology and Biotechnological Equipment, 26 134 – 139, ISSN: 0003-6072 |
| 2012 | Georgieva M., Roguev A., Balashev K., Zlatanova J., Miloshev G. 2012. Hho1p, the linker histone of Saccharomyces cerevisiae, is important for the proper chromatin organization in vivo. BBA Gen Reg Mechanisms, 1819 (5): 366-374, ISSN: 1874-9399 |
| 2012 | Miloshev M, Peycheva E, Georgieva M. 2012. A sensitive method detects DNA damages caused by food additives. Journal of the Bulgarian Academy of Sciences, 1, 10-14. ISSN: 0007-3989 |
| 2011 | Georgieva, M. and Miloshev, G. 2011. To age like a cathedral. Article in the popular science magazine – “Eight” 4, April; pp: 70-75; ISSN 1313-650X |
| 2009 | Miteva, R., Georgieva, M., Peycheva, E., Еfremоv, T., Miloshev, G. 2009. Development of conditions for comet assay application in forensic investigation of rape and other sexual assaults. Biotechnology and Biotechnological Equipment 23 (1), pp. 1093-1094 |
| 2009 | Peycheva, E., Georgieva, M., Miloshev, G. 2009. Comparison between alkaline and neutral variants of yeast comet assay. Biotechnology and Biotechnological Equipment 23 (1), pp. 1090-1092 |
| 2009 | Georgieva, M., Еfremоv, T., Alexandrova, R. and Miloshev, G. 2009. Comet Assay discriminates levels of chromatin compaction, Comptes Rendus de L'Academie Bulgare des Sciences 62 (4), pp. 479-484 |
| 2009 | Miloshev, G., Staneva, D. and Georgieva, M. 2009. Epigenetics: we are the way we live |
| 2008 | Georgieva, M., Harata, M. and Miloshev, G. The nuclear actin-related protein Act3p/Arp4 influences yeast cell shape and bulk chromatin organization, J Cellular Biochem, 2008 May 1;104(1): 59-67 |
| 2008 | Draganova-Filipova, M., Georgieva, M., Peycheva, E., Miloshev, M., Sarafian, V. and Peychev, P. 2008. Effects of propolis and CAPE on proliferation and apoptosis of McCoy-Plovdiv cell line. Folia Medica 1: 53-59 |
